Epidiolex, a refined version of CBD oil, was approved for prescription use by the Food and Drug Administration (FDA) in June 2018 for the treatment of two kinds of epilepsy. Other states have legalized other types of cannabis.
Numerous chemical constituents in cannabis provide a diverse array of effects. Some can be used as a treatment, but not all. Many types of marijuana are permitted in certain states.
We’ll look at what CBD is, how it can help health, how to use it, the hazards it may have, and the legal status of CBD in the United States in this article. CBD is a cannabinoid found in hemp.
Is CBD legal in the United States?
It was removed from the Controlled Substances Act’s description of marijuana in the 2018 Farm Bill. CBD products containing less than 0.3 percent THC are now allowed in the United States.
CBD products with more than 0.3 percent THC, on the other hand, are still classified as marijuana under federal law but are allowed in several states.
When traveling, it’s extremely important to familiarise yourself with local regulations. Nonprescription CBD products have not been given FDA approval, and some may have incorrect labels.
Relieves Aching Joints
2900 B.C. marks the earliest known usage of cannabis for the treatment of pain (2Trusted Source).
The pain-relieving properties of cannabis may now be attributed to certain cannabinoids, including CBD.
One of the most important systems in the body is the Endocannabinoid System (ECS), which controls everything from sleep to appetite to pain sensation to the immune system’s reaction (3Trusted Source).
In your neurological system, cannabinoid receptors bind to endocannabinoids, which are neurotransmitters produced by your body.
Endocannabinoids, inflammation, and neurotransmitters are all thought to be affected by CBD, which suggests that it may be useful in treating chronic pain (4Trusted Source).
When used alone, CBD, according to some studies, may be beneficial in the treatment of certain forms of pain, such as nerve and back pain. However, the combination of THC and CBD appears to be most effective (5Trusted Source, 6Trusted Source).
Multiple sclerosis (MS) and rheumatoid arthritis symptoms can be alleviated by combining CBD and THC.
Several nations have licensed an oral spray called Sativex (nabi ximols), a 1:1 mixture of THC and CBD, to alleviate MS-related pain.
Sativex was studied for a month in research including 47 persons with MS. Pain, mobility, and muscle spasms were reduced among the individuals (7Trusted Source).
However, because a control group was omitted from the trial, it is impossible to rule out the possibility of placebo effects (7Trusted Source).
Those with MS-related neuropathic pain and persistent severe neuropathic pain may benefit from using Sativex, according to a recent review. Anxiety and stress are important contributors to chronic pain, according to the study (8Trusted Source).
Fibromyalgia and other rheumatic disorders may also benefit from CBD, according to some studies.
A study including 2,701 fibromyalgia sufferers found that individuals who took CBD for pain management saw improvements in their symptoms that ranged from slight to significant (9Trusted Source).
It has been suggested that CBD may have positive effects on arthritic pain and inflammation, however, human trials are still lacking (10Trusted Source).2. Symptoms of various mental health conditions may be lessened
A person’s general health and well-being can be severely harmed by anxiety disorders and other mental health issues.
Drugs used to treat mental health issues can have a variety of side effects, including drowsiness, agitation, sleeplessness, sexual dysfunction, and headaches (11Trusted Source).
Benzodiazepines, for example, can cause dependence and, in certain cases, drug abuse disorder.
Since CBD oil has shown promising results for anxiety disorders and other mental health issues, many people who suffer from these conditions have been interested in this method to treatment.
An oral CBD or placebo was administered to 57 Brazilian men 90 minutes prior to a simulated public speaking test. The highest beneficial dose of CBD for lowering test anxiety was determined to be 300 milligrams, according to the researchers (12Trusted Source).
Those who received the placebo, a 150-mg dose of CBD, or a 600-mg dose of CBD reported little to no effect (12Trusted Source).
Anxiety and insomnia in children with post-traumatic stress disorder (PTSD), a kind of anxiety illness, have been successfully treated with CBD oil (13Trusted Source).
CBD was also proven to be beneficial in individuals suffering from PTSD-related symptoms such as nightmares in recent small research (14Trusted Source).
Other research suggests that CBD may be helpful for people suffering from social anxiety and other anxiety-related conditions (15Trusted Source).
Human evidence for CBD’s antidepressant effect is currently limited despite the fact that some people report that CBD alleviates symptoms of depression (15Trusted Source).
Several studies, on the other hand, suggest that it may help people with cannabis use problems reduce their depressive symptoms (15Trusted Source).
Ongoing studies are looking at the effects of CBD on anxiety and depression symptoms.
People with bipolar disorder are expected to complete a trial assessing the potential benefit of 150–300 mg of CBD per day for 12 weeks on symptoms of anxiety and depression in April 2022. (15Trusted Source).
CBD has been demonstrated to help alleviate some of the symptoms of anxiety disorders. CBD is currently being studied by researchers to see if it might be used to treat different forms of mental illness.
Can help with some of cancer’s side effects
Nausea, vomiting, and pain may all be eased by CBD oil, which has been shown to aid with cancer symptoms and treatment side effects.
A previous study examined the effects of CBD and THC on 177 persons with cancer-related pain who were unable to alleviate their symptoms with conventional painkillers.
Both THC and an extract combining both chemicals reduced pain significantly more than THC extract alone (16Trusted Source).
an assessment of five research revealed some evidence that Sativex may benefit persons suffering from cancer-related discomfort (17Trusted Source).
The results of cancer-related nausea, discomfort, and decreased appetite have been mixed in research on cannabis and cannabinoids such as CBD (18Trusted Source).
Even though CBD may be beneficial for some cancer patients, additional research is needed to establish whether CBD should be used more frequently to control cancer symptoms.
CBD and other cannabis-derived products should only be used in conjunction with professional medical advice if someone has cancer and wants to use them. Some patients with cancer may be ineligible for the benefits of these items due to a variety of factors.
SUMMARY While research suggests that cannabidiol (CBD) may alleviate some of the symptoms of cancer in some people, the results are currently mixed, and further research is needed to determine the substance’s efficacy and safety.
Possibility of neuroprotective effects
Neurological illnesses may benefit from CBD’s capacity to affect the endocannabinoid system and other brain-signaling systems.
CBD, on the other hand, has been examined extensively for its ability to treat neurological illnesses like epilepsy and multiple sclerosis. Even though this field of study is still in its infancy, a number of intriguing investigations have already been conducted.
Muscle stiffness in persons with MS can be effectively and safely reduced with Sativex.
276 persons suffering from muscle spasticity that was unresponsive to medicines saw a 75% reduction in their spasms after taking this drug (19Trusted Source).
More than 200 persons with severe epilepsy were given between 0.9–2.3 milligrams of cannabidiol oil per pound (2–5 milligrams per kilogram). The frequency of their seizures decreased by a median of 36%. (20Trusted Source).
Dravet syndrome, a complicated juvenile epilepsy illness, was found to be considerably reduced in children given CBD oil compared to those who received a placebo (21Trusted Source).
However, CBD medication caused side effects like seizures, fever, and exhaustion in some participants in these two investigations.
The therapeutic potential of CBD in the treatment of various other neurological disorders has also been studied.
CBD, for example, has been found to improve the quality of life and sleep quality of Parkinson’s disease patients (22Trusted Source).
Researchers, on the other hand, say that there is a dearth of high-quality data at the moment. That indicates there isn’t enough evidence to justify the clinical usage of CBD for Parkinson’s disease treatment (22Trusted Source).
However, the FDA has approved one CBD product for use in the treatment of a number of seizure conditions.
For the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome, the FDA authorized Epidiolex, a prescription cannabidiol medication, in 2018.
To treat seizures caused by tuberous sclerosis complex, a rare genetic illness that causes benign brain tumors to develop and spread throughout the body, Epidiolex obtained FDA approval in 2020. (23Trusted Source).
Seizures caused by a variety of medical disorders may benefit from CBD, according to a study. Patients with Dravet syndrome or other diseases known to cause seizures can now use Epidiolex, a prescription CBD medication, with FDA approval.
May improve cardiovascular health
In certain studies, CBD has been related to a number of cardiovascular health advantages, including the capacity to reduce excessive blood pressure.
A range of health disorders, including stroke, heart attack, and metabolic syndrome, are connected to high blood pressure (24Trusted Source).
CBD may have a positive effect on persons with high blood pressure, according to research.
In a tiny trial, nine healthy men were given 600 mg of CBD oil each day for two weeks. Compared to a placebo, the CBD treatment lowered resting blood pressure (25Trusted Source).
Stress tests, which often raise blood pressure, were also performed on the men as part of the same study. It was interesting to note that a single dose of CBD reduced the men’s blood pressure response to these tests (25Trusted Source).
Compared to a placebo group, 26 healthy males taking 600mg of CBD for seven days saw significant reductions in blood pressure in the short term. However, after seven days, the effect had faded (26Trusted Source).
After repeated dosages, the CBD group had lower blood pressure in reaction to stress than the placebo group.
Researchers also showed that CBD users had reduced arterial stiffness and enhanced blood flow through their arteries following long-term use, compared to placebo users (26Trusted Source).
While these results are encouraging, additional research is needed to determine whether CBD medication might improve cardiovascular health.
Studies on CBD’s cardiovascular benefits are still lacking, but preliminary findings suggest that it can lower blood pressure and improve arterial health.